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Insulin is given by subcutaneous injection. The needle is injected into the fatty tissue just below the skin layer and above the muscle. See the information below on “rotating” injection sites. Make sure skin is clean: It is generally not necessary to wipe the skin with alcohol before. o Support and assist patient in self-injecting insulin now o Discuss possible injection sites and injection rotation o Use patient literature to explain the HOW TO USE AN. INSULIN PEN. Pick the Place (Site) to Inject. Sites to inject include: s s s s. Taking Your Insulin. 1. Clean the skin with an alcohol pad. Preparing and injecting with a reusable insulin pen . To maintain healthy injection sites, only use Follow local guidelines where applicable. Insulin Injection Guidelines. Step 1: Wash your hands. Step 2: Mix your cloudy insulin by gently rolling it 10 times and tipping it (not shaking.Demonstrate the steps of giving an insulin injection. Syringes, needles, and guidelines for reusing and disposal of syringes . . . . . . . . . . .O-12. Insulin Injection Sites Insulin that is cloudy (NPH, premixed) needs to be mixed before using. Diabetes Driving Guidelines.