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BYETTA is injected twice a day, the pen contains enough medicine for 30 days. You do not have to measure any doses, the pen measures each dose for you. DO NOT Each BYETTA Pen contains enough medicine for injection two times each day for 30 days. You do not have to measure any doses, the pen measures each dose for Read this Medication Guide and the Pen User. Manual that come with BYETTA before you start using it and each time you get a refill. There may be new informationRead these instructions carefully BEFORE using your Byettapen. Byetta is injected twice a day, the pen contains enough medicine for 30 days. Using Your Byetta Pen. Medicine: Exenatide (ex-EN-a-tide). To see a video showing how to use the pen, visit fpanetwork.org/diabetes. Storing your pens.