October 13, 2016. The AABB has recently published updated guidelines for red blood cell (RBC) transfusion thresholds and the optimal length of storage. Based on a comprehensive systematic review and meta-analysis incorporating 31 randomized controlled trials, the AABB strongly recommends a restrictive hemoglobin transfusion threshold of 7g/dL Guidelines on Transfusion for Fetuses, Neonates and Older Children; Red Blood Cell Transfusions in Newborn Infants; Guidelines for Transfusion Therapy of Infants from Birth to Four Months of Age; Obstetric / Gynaecologic. No. 133-Prevention of Rh Alloimmunization; Guideline for blood grouping and red cell antibody testing in pregnancy Whole Blood must be placed in storage at a temperature between 1 and 6 deg.C immediately after collection unless the blood is to be further processed into another component or the blood must be transported from the donor center to the processing laboratory. The Compendium of Transfusion Practice Guidelines, written by the American Red Cross Medical Office offers an updated compilation of peer-reviewed literature covering the utilization of red blood cells, platelets, plasma, and cryoprecipitated-AHF, as well as the role of transfusion committees and the side effects and hazards of blood transfusion. The Compendium is available via a mobile app ( Apple or Android) or hardcopy. Apheresis devices are continuous systems that remove blood from a donor, separate the blood into the desired components and return the remaining blood back to the donor. In the U.S., the collection, testing, preparation, storage and transport of blood and blood components must comply with FDA regulations and guidance documents. guidance for the safe storage, handling and use of clinical samples. 1. Scope and Principles 1.1 The term clinical sample is used to encompass: • all blood, blood products and derivatives, bodily fluids, excretions and tissues, • sourced from either human or animal donors, • donated or purchased. 1.2. The "Guide to Inspections of Blood Banks" is a consolidation of information previously provided in the Blood Bank Inspection Checklist and Report, and the Instruction Booklet for Blood Bank Inspection Checklist and Report, FDA-2609. This guide, which provides the most updated interpretation of certain regulations and guidelines, was prepared by The 'Red Book' (as the printed version of these guidelines are known) aims to define guidelines for all materials produced by the United Kingdom Blood Transfusion Services for both therapeutic and diagnostic use. The guidelines reflect an expert view of current best practice, provide specifications of products, and describe technical details of processes .Every effort has been made to ensure that the guidelines reflect the legally binding requirements of the Blood Safety (and Quality) and Blood Bank/Transfusion Service Guidelines. Possible Strategies for Reduction of Transfusion-related Errors First Edition, 2000. Responsibilities of Blood Bank Director, Blood Bank Medical Director and Director of Transfusion Services Second Edition, 2012. Guidelines for Transfusion Committees Third Edition, 2006. Storage and handling. Blood components must be stored at the appropriate temperature as shown in the following tables. Failure to follow correct storage requirements may result in decreased transfusion efficacy, potential harm to the patient or the component being unsuitable for use and discarded. WHO Guidelines may be adopt