Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) by linear trapezoidal method Description It calculates AUC and AUMC using linear trapezoidal method Usage LinAUC (x, y) Arguments Details This function returns AUC and AUMC by linear trapezoidal method. Value Author (s) Kyun-Seop Bae References The daily area under the curve (AUC 24) of serum concentration versus time to minimum inhibitory concentration (MIC) ratio of greater than 400 mg × h/L has emerged as a more robust dosing target. A simple and practical method to extrapolate AUC 24 from troughs is needed. Methods: Description Calculate Area Under the Curve (AUC) and the first Moment Curve (AUMC) in two ways; 'linear trapezoidal method' or 'linear-up and log-down' method. Return a table of cumulative values. Usage AUC (x, y, down = "Linear") Arguments Details OBJECTIVE. Updated vancomycin guidelines suggest dose adjustment based on area under the curve in a 24-hour period (AUC24). This study aims to determine whether a pharmacist managed vancomycin protocol that incorporates maximum dosing paired with trough monitoring can achieve appropriate vancomycin AUC24 exposures.METHODS. A retrospective review was performed evaluating vancomycin usage from in an open-label, prospective, pharmacokinetic assessment, we evaluated total drug exposure (area under the curve [auc]) of intravenous (iv) ganciclovir (gcv) and oral (p.o.) valganciclovir when normalized for body surface area (bsa) in pediatric liver (n=20) and renal (n=26) transplant patients reference doses for iv gcv (200 mg/m (2)) and p.o. … The human oral pharmacokinetics of cefadroxil were studied in parallel at doses of 250, 500, and 1,000 mg in three groups of 10 healthy young male volunteers. Renal excretion of intact cefadroxil, accounted for 82, 79, and 77% of the above doses. Mean peak serum levels were dose linear: 9, 18, and 35 microgram/ml at 250, 500, and 1,000 mg Area Under a Curve is a statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral in a plot of drug concentration in blood plasma vs. 80 relations. Area under the curve (pharmacokinetics) and Blood plasma · See more » Capsule (pharmacy) In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories. The daily area under the curve (AUC24) of serum concentration versus time to minimum inhibitory concentration (MIC) ratio of greater than 400 mg*hr/L has emerged as a more robust dosing target. I got this from Wikipedia in February 2017 for learning purposes. Area Under The Curve AUC. Module 6-Area Under The Curve. Introduction to pharmacokinetics; IV administration Area Under The Curve AUC. Module 6-Area Under The Curve. Introduction to pharmacokinetics; IV administration The pharmacokinetics of primaquine have been examined in five healthy volunteers who received single oral doses of or route of administration. The relationships between area under the curve and dose size were linear for both primaquine (r = 0.99, P less than or