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Clopixol Acuphase contains the acetate ester of zuclopenthixol. However, data from open trials of zuclopenthixol in the treatment of mania and acute paranoid psychosis indicate that the . Depot, the following guidelines should be used: 1. 26 Jan 2017 Maximum dosage per injection should be 100 mg. The MDT should consider withholding other anti-psychotic treatment for at least 3 days following Zuclopenthixol Acetate injection. Onset of action: Sedative effects usually begin to be seen 2 hours after injection with peak serum concentrations between 12 and 36 hours. 1 Jan 2018 at least 15 minutes after IV injections and at least 60 minutes after those administered intramuscularly. sedation and/or aggravated adverse events may occur if the patient is exposed to high plasma levels of multiple drugs. 2 or 3 days. The maximum dose per injection for an elderly patient is 100mg (2ml). 18 Apr 2012 Guidance on the Use of Zuclopenthixol Acetate (Clopixol Acuphase) psychiatric emergencies in preference to 'standard' treatment should be 50–100 mg, then 50–100 mg after 2–3 days if required, (1 additional dose may be needed 1–2 days after the first injection); maximum cumulative dose 400 mg in 2 weeks and maximum 4 injections; maximum duration of treatment 2 weeks—if maintenance treatment necessary change to an oral antipsychotic 2–3 days after last continued during zuclopenthixol acetate therapy if considered of clinical importance or zuclopenthixol decanoate i.m., after the following guidelines:.1 Apr 1996 This formulation of zuclopenthixol is indicated for the treatment of acute psychoses, mania or exacerbations of chronic psychoses. Zuclopenthixol acetate in the treatment of acute schizophrenia and similar CONCLUSIONS: Recommendations on the use of zuclopenthixol acetate for the Guidelines for the use of zuclopenthixol acetate (Clopixol. Acuphase. ®. ) Acuphase® is licensed as “initial treatment of acute psychoses, including mania and.