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BACTRIM prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects. BACTRIM (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination available in DS (double strength) tablets, each containing 800 mg Bactrim DS tablets contain 800mg sulfamethoxazole and 160mg Minimum dosage: half a Bactrim DS (double strength) tablet twice daily (see below). 160 mg trimethoprim/800 mg sulfamethoxazole PO every 12 hours. The Infectious Diseases Society of America (IDSA) recommends a 3 day treatment course fortrimethoprim/sulfamethoxazole (Rx) Documented Pneumocystis jiroveci pneumonia (PCP); also, prophylaxis against PCP in individuals who are immunosuppressed. Tablet: 80-160 mg TMP PO qDay or 160 mg TMP 3 times/week on consecutive or alternate days.