Free, official coding info for 2019 HCPCS J2993 - includes code properties, rules & notes nd more. Medscape - Indication-specific dosing for Retavase (reteplase), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The tenecteplase 50 mg dose was replaced with tenecteplase 40 mg, and there was a downward adjustment in heparin dosing. After initiating a lower dose of tenecteplase and a heparin protocol, the incidence of intracranial and serious bleeding was lower in all treatment groups. MI, and for standard stroke results in approximately 1mcg/ml of CC, now this is an incredibly low serum level dose, but it works, and that just shows you how powerful this drug is. So if we're gonna duplicate that with an intra-aterial dose, we have to give something that is incredibly low. We've done some [] TNKase® (Tenecteplase) DESCRIPTION TNKase® (Tenecteplase) is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese Hamster Ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following Methods. ASSENT-2 was a randomized, double-blinded, double placebo-controlled clinical trial designed to assess the efficacy of weight-adjusted dosing of TNK versus front-loaded t-PA in 16,949 patients, and the results have been presented elsewhere.5 In brief, from October 1997 to November 1998, patients aged ?18 years were recruited from 1,021 hospitals in 29 countries with symptoms of AMI Tenecteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.. Tenecteplase is used to prevent death in people who have had a heart attack (acute myocardial infarction).. Tenecteplase may also be used for purposes not listed in this medication guide. Precautions. Drug information provided by