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Pathophysiology. A stroke occurs when the blood flow to an area of the brain is interrupted, resulting in some degree of permanent neurological damage. Ischemic stroke—when the blood supply to the brain is blocked. • Hemorrhagic stroke—when a blood vessel in the brain What are the signs and symptoms?Textbook of Stroke Medicine - September 2014. A PDF of this content is also available in through the 'Save PDF' action button. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke,