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Adults: 10 mg IV or IM as a single dose, followed by 4 mg IV or IM every 6 hours, until symptoms subside, then reduce dosage. A response should be seen withinHow should I take dexamethasone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may DexPak 10-day TaperPak Tablet ECR Pharmaceuticals Frequently Asked Questions (FAQs) on DexPak TaperPak: Oral tablet. Close Show Response is usually noted within 12 to 24 hours and dosage may be reduced after two to four days and gradually discontinued over a period of five to seven days.