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FRONTLINE Plus spreads from the single point of application ENTIRE LABEL AND DIRECTIONS BEFORE lice apply FRONTLINE Plus for Dogs as follows:. Treat all your dogs and cats every month. When applied correctly, FRONTLINE PLUS remains active on your pet's skin for one month. If you are in a paralysis tick area, apply FRONTLINE PLUS every 2 weeks to provide paralysis tick control for your dog. If I notice a tick on my pet, what's the best course of action? Should I use FRONTLINE Plus on my pet all year round? Or just during flea and tick season? Get Frontline Plus spot-on topical flea and tick treatment for dogs. Easy to apply topical monthly flea and tick product protects all month long; Aids in the Directions: To kill fleas and all stages of brown dog ticks, American dog ticks, lone star7 Jul 2016 FRONTLINE Plus for Dogs - Orange, For Dogs 5 to 22 lbs. Directions 30 days, even if your dog or cat swims or is bathed; Gentle enough for use on puppies Frontline Plus for small dogs and apply as per the instructions for Apply the Frontline to your pet's skin. Place the tip of the applicator onto your pet's skin. Squeeze the vial and empty all of the liquid onto your pet's skin. Try to avoid getting any liquid on your pet's hair. Learn about FRONTLINE Plus for Dogs & Puppies for animal usage including: active ingredients, directions for use, precautions, and storage information. Open Applicator: Hold upright with foil side toward you and snap applicator tip. Apply FRONTLINE Plus: Part your dogcat's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin.